Controlled Double Blind Studies with Cold Laser Therapy
Following is a list of cold laser controlled, randomized, double-blind studies,* which have shown that Cold Laser Therapy is an effective treatment modality for a wide range of treatment indications such as:
- Acne Vulgaris
- Achilles tendonitis
- Ankle sprains
- Arthritis
- Carpal tunnel syndrome
- Chronic back pain
- Chronic neck pain
- Epicondylitis
- Herpes simplex
- Lymphedema
- Myofascial pain syndrome
- Oral mucositis
- Shoulder pain
- Sports injuries
- Stroke
- Temporomandibular dysfunction
- Tinnitus
*Achilles tendinitis: Bjordal, J.M., et al. (2006). A randomized, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. British
Journal of Sports Medicine 40, pp. 75-80.
Acne vulgaris: Seaton, E.D., et al. (2003). Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. The Lancet 362, pp. 1347-1352. Acute pain
(Review paper): Bjordal, J.M., et al. (2006). Low-Level Laser
Therapy in Acute Pine: A Systematic Review of Possible Mechanisms of Action and Clinical Effets in Randomized Placebo-Controlled Trials.
Photomedicine and Laser Surgery 24(2), pp. 158-168.
Carpal tunnel syndrome: Ekim, A., et al. (2007). Effect of low level laser therapy in rheumatoid arthritis patients with carpal tunnel syndrome.
Swiss Medical Weekly 23-24, pp. 347-352.
Chronic neck pain: Chow, R.T., et al. (2006). The effect of 300 mW, 830 nm laser on chronic neck pain: A double-blind, randomized, placebo-controlled study.
Pain 124(1-2), pp. 201-210.
Herpes simplex: Schindl, A., and Neumann, R. (1999). Low-Intensity Laser Therapy is an Effective Treatment for Recurrent Herpes Simplex Infection. Results from a Randomized Double-Blind Placebo-Controlled Study.
Investigative Dermatology 113, pp. 221-223.
Myofascial Pain Syndrome
Gur, A., et al. (2004). Efficacy of 904 nm Gallium Arsenide Low Level Laser Therapy in the Management of Chronic
Myofascial Pain in the Neck: A Double-Blind and Randomize-Controlled Trial.
Lasers in Surgery and Medicine 35, pp. 229-235.
Oral mucositis: Bensadoun, R.J., et al. (1999). Low-energy He/Ne laser in the prevention of radiation-induced mucositis – A multicenter phase III randomized study in patients with head and neck cancer.
Support Care Cancer 7, DOI 10.1007/s005209900034.
Osteoarthritic knee pain
(Review paper): Bjordal, J.M., et al. (2007). Short-term efficacy of physical interventions in Osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials. BNC
Musculoskeletal Disorders, DOI 10.1186/1471-2474-8-51.
Postmastectomy lymphedema
Carati, C.J., et al. (2003). Treatment of Postmastectomy Lymphedema with Low-Level Laser Therapy.
American Cancer Society, DOI 10.1002/cncr.11641.
Stroke: Lampl, Y., et al. (2007).
Infrared Laser Therapy for Ischemic Stroke: A new Treatment Strategy. Results of the NeuroThera Effectiveness and Safety Trial-1
(NEST-1). Stroke, DOI 10.1161/STROKEAHA.106.478230.
Tendinitis and Myofascial Pain Syndrome
(includes Epicondylitis, trochanteritis, etc): Lögdberg-Andersson, M., et al. (1997). Low Level Laser Therapy (LLLT) of Tendinitis and Myofascial Pains – A Randomized, Double-Blind, Controlled Study. LLLT 9, pp. 79-86.
Tinnitus: Gungor, A., et al. (2007).
Effectiveness of transmeatal low power laser irradiation for chronic tinnitus.
The Journal of Laryngology & Otology, DOI 10.1017/S0022215107009619
